Job Description

Hi,

My name is Gaurav, and I am a recruiter with Net2Source Inc. Our direct client is looking to hire a Scientist - II (Associate) - PA/NJ Only in their growing team.

Please find below the job description.

Title: Associate Scientist - II :: Ligand Binding

Duration: 06 months (Extendable)

Location: Rahway NJ 07065

No benefits

Must Haves/Required skills:

• Prior experience developing equilibrium and kinetic radioligand binding assays (e.g. 125I, 3H, 35S) in relevant formats is preferred, or willingness to do radioligand work.

• Tissue culture including: (i) cell plating, (ii) cell stimulation and (iii) cell harvesting.

• Experience in membrane preparation

• Experience working with multiwell plates (96- and 384-well formats)

• Note that this position is laboratory-based.

**** is looking for a contractor for their early drug discovery team. This is a very dynamic, fast paced department.

Our Mission statement:

Mass Spectrometry & Biophysics

Based in Rahway, NJ the Mass Spectrometry & Biophysics (MSB) team is an integral part of the Computational & Structural Chemistry Department within Discovery Chemistry. Working across all therapeutic areas & supporting teams at all network sites we focus our efforts in 3 principal areas to drive end-to-end pipeline impact:

1. Screening & Hit-to-Lead. Discovery & optimization of ligands across the modality spectrum (fragments, small molecules, bifunctional degraders, peptides, therapeutic proteins) to identify leads that modulate our targets of interest.

2. Elucidating Mode of Interaction. Detailed characterization of how our ligands interact with and modulate our targets of interest at the molecular level.

3. Understanding Mechanism of Action. Determining how perturbing our targets of interest affects disease pathology both in vitro and in vivo.

Core responsibilities:

• Run routine radioligand binding assay protocols, analyze data & generate weekly reports, carry out tissue culture and cell-based binding assays.

• Fully document all experiments in our electronic laboratory notebook.

Qualifications

Education: B.Sc. with 6+ years or M.Sc. with 4+ year or PHD with 3+ years of laboratory experience practicing the required skills.

Nice to haves/Preferred skills:

• Experience with liquid handling automation systems (e.g. Echo, Bravo).

• Familiarity with multi-mode plate readers such as the SpectraMax and EnVision Multilabel Reader.

• Exporting and dose-response fitting of data from binding assays.

• Running research operating plan assay and data upload (ROP assay, ActivityBase application)

• Experience with traditional Western blot techniques, including requisite data analysis used to determine abundance of given protein targets. Knowledge of the Protein Simple high-throughput, automated western blotting system is preferred but not required.

Computer/Software skills:

• MS Office suite, Adobe PDF –must have

• Prior experience with an electronic laboratory notebook system is desirable but not required.

• Prior experience with data analysis packages including GraphPad Prism, Activity Base, etc. is desirable but not required.

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